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doi: 10.3389/fendo.2021.667066 70 AgusADenizotJThvenotJMartinez-MedinaMMassierSSauvanetPet al

Nrf2 pathway is a major target for sulforaphane

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Loss of BRCA1 function caused by BRCA1 mutation results in the production of hydrogen peroxide in both epithelial breast tumor cells and adjacent stromal fibroblasts, which is able to promote the onset of a reactive glycolytic stroma, suggesting the metabolic phenotype of stromal cells in the TME may also be affected by BRCA1 mutation in tumor cells (225)